Doxy PEP has been shown in studies to work well for persons who were assigned male at birth who have sex with other persons who were assigned male at birth.
You might consider Doxy PEP if:
- You've been diagnosed with a bacterial STI in the last year (12 months)
- You've had condomless oral or anal sex in the last year (12 months)
More research is needed on Doxy PEP effectiveness for people assigned female at birth and those who have vaginal sex. However, if you would benefit from Doxy PEP, talk to your provider to see if it’s an option for you.
- Take two 100mg pills no later than 72 hours after sex.
- If possible, take Doxy PEP within 24 hours of having sex. It may be more effective the sooner you take it.
- If you have sex again within 24 hours of taking Doxy PEP, take Doxy PEP again 24 hours after your last dose.
- You can take Doxy PEP as often as once a day when you are having sex.
- Don’t take more than 200 mg (two 100 mg pills) every 24 hours.
Example: Occasional sex
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You have sex on a Monday afternoon.
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Take Doxy PEP by Thursday afternoon.
Example: Sex on multiple days
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You have sex on Sunday at 9 p.m. then take Dose 1 of Doxy PEP at 11 p.m.
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You then have sex on Monday at 8 a.m. Dose 2 of Doxy PEP is due at 11 p.m. or later.
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You have sex on Wednesday at 7 p.m. Take Dose 3 of Doxy PEP soon after sex – by Saturday at 7 p.m.
- Upset stomach
- Esophagus (throat) irritation
- Rash or skin sensitivity to sun
To avoid or alleviate side effects:
- Take Doxy PEP with food and a large glass of water.
- Stay upright for 30 minutes after taking Doxy PEP to prevent esophagus (throat) irritation.
- Avoid dairy products, calcium, antacids, or multivitamins 2 hours before and after taking Doxy PEP.
- Wear sunscreen and stay covered or in the shade to avoid skin rashes from the sun while taking Doxy PEP.
If you have insurance, Doxy PEP should be low-cost or free.
If you do not have insurance, ask to speak with our Benefits Navigator for MNsure application assistance.
Even if you've been taking Doxy PEP, make an appointment or walk in to be seen. Let us know you have symptoms so we can book enough time for your appointment.
Do not use Doxy PEP to treat infections on your own. A trusted provider will help you get the correct medication.
If your partner tested positive for:
- Gonorrhea or chlamydia: Doxy PEP will prevent most infections. Get tested 7 days after exposure to be sure.
- Syphilis: Call the clinic to make an appointment for testing and treatment.
You will need a follow-up appointment every 3 months to discuss your Doxy PEP use and STI screening. Call us at 612-543-5555 to schedule an appointment.
Contact the clinic via phone or MyChart if you are having concerns or need a refill.
Call our nurse line at 612-543-5555 during regular clinic hours if you have questions or concerns about Doxy PEP.
